College of Chemistry and Molecular Engineering, Peking University, Haidian District, Beijing 100871, China
RESEARCH
RESEARCH
Research direction
We work at the interface of chemistry and biology. Centered around leveraging the live-cell chemistry for mechanistic discovery and therapeutic innovations, we have developed bioorthogonal reactions and chemical probes to understand protein functions and cell communications in health and disease. We employ this toolkit to study how the spatial-temporally organized human proteome is rewired in cancer as well as during immune response, and we also exploit the therapeutic potential of these new discoveries. Research areas in the group include: